Article Navigation
Journal Article Accepted manuscript
Get access
, Kaoruko Komuro, MD Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan Search for other works by this author on: Oxford Academic Hidehiro Kaneko, MD Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan Department of Advanced Cardiology, The University of Tokyo , Tokyo , Japan Correspondence: Hidehiro Kaneko, MD, PhD., The Department of Cardiovascular Medicine, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, Phone: +81 33815 5411 Fax: +81 35800 9171, E-mail: kanekohidehiro@gmail.com Search for other works by this author on: Oxford Academic Jin Komuro, MD Department of Cardiology, Keio University School of Medicine , Tokyo , Japan Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan Search for other works by this author on: Oxford Academic Yuta Suzuki, PhD Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan Center for Outcomes Research and Economic Evaluation for Health, National Institute of Public Health , Saitama , Japan Search for other works by this author on: Oxford Academic Akira Okada, MD Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan Search for other works by this author on: Oxford Academic Atsushi Mizuno, MD Department of Cardiovascular Medicine, St. Luke's International Hospital , Tokyo , Japan Leonard Davis Institute for Health Economics, University of Pennsylvania , Philadelphia, PA , USA Search for other works by this author on: Oxford Academic Katsuhito Fujiu, MD Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan Department of Advanced Cardiology, The University of Tokyo , Tokyo , Japan Search for other works by this author on: Oxford Academic Norifumi Takeda, MD Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan Search for other works by this author on: Oxford Academic Hiroyuki Morita, MD Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan Search for other works by this author on: Oxford Academic Koichi Node, MD Department of Cardiovascular Medicine, Saga University , Saga , Japan Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0003-2553-6170 , Hideo Yasunaga, MD Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo , Tokyo , Japan Search for other works by this author on: Oxford Academic Norihiko Takeda, MD Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan Search for other works by this author on: Oxford Academic Masaki Ieda, MD Department of Cardiology, Keio University School of Medicine , Tokyo , Japan Search for other works by this author on: Oxford Academic Issei Komuro, MD Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan International University of Health and Welfare , Tokyo , Japan Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan Search for other works by this author on: Oxford Academic
European Journal of Preventive Cardiology, zwae221, https://doi.org/10.1093/eurjpc/zwae221
Published:
01 July 2024
Article history
Received:
05 April 2024
Revision received:
25 June 2024
Accepted:
28 June 2024
Published:
01 July 2024
- Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
-
Cite
Cite
Kaoruko Komuro, Hidehiro Kaneko, Jin Komuro, Yuta Suzuki, Akira Okada, Atsushi Mizuno, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Norihiko Takeda, Masaki Ieda, Issei Komuro, Differences in the Association of Lifestyle-Related Modifiable Risk Factors with Incident Cardiovascular Disease Between Individuals with and without Diabetes, European Journal of Preventive Cardiology, 2024;, zwae221, https://doi.org/10.1093/eurjpc/zwae221
Close
Search
Close
Search
Advanced Search
Search Menu
Abstract
Aims
Individuals with diabetes have a high risk of developing cardiovascular disease (CVD). Little was known whether the association between modifiable risk factors and incident CVD would change according to the presence of diabetes.
Methods
In this study, we analyzed 4,132,006 individuals including 173,262 individuals (4.2%) with diabetes registered in the JMDC Claims Database, and compared the association between modifiable risk factors and risk of CVD between individuals with and without diabetes.
Results
The median age was 44 years, and 57.5% were men. Multivariable Cox regression analyses showed that the relationship of obesity, hypertension, and dyslipidemia with incident CVD was attenuated in individuals with diabetes, whereas that of non-ideal eating habits, smoking, and physical inactivity with incident CVD was pronounced in those with diabetes. The hazard ratio per 1-point increase in non-ideal lifestyle-related factors was 1.03 [95% confidence interval (CI) 1.03-1.04] in individuals with non-diabetes, whereas 1.09 [95% CI 1.07-1.11] in individuals with diabetes (p-value for interaction < 0.001). Further, hazard ratios for developing CVD were 1.02 [95% 1.01-1.04] in individuals not having diabetes, whereas 1.09 [95% CI 1.04-1.13] in individuals having diabetes for the increase of lifestyle-related factor after 1-year follow-up (p-value for interaction 0.007).
Conclusion
Our analysis utilizing a nationwide epidemiological dataset presented that the relationship of lifestyle-related factors with incident CVD would be pronounced in people having diabetes, suggesting that the maintenance of a healthy lifestyle would play a more important role in the development of CVD in individuals having diabetes. (244 words)
Graphical Abstract
Open in new tabDownload slide
Lay Summary
Our investigation utilizing a nationwide epidemiological cohort showed a pronounced relationship of lifestyle-related factors with incident CVD in individuals with diabetes.
The HRs (95% CI) for the occurrence of CVD events showed a progressive increase with each additional lifestyle-related factor. This trend was more prominent among individuals with diabetes than those without diabetes.
The association between changes in the number of lifestyle-related factors over a year and the risk of developing CVD was also more pronounced in individuals with diabetes.
These results suggest that maintaining healthy lifestyle habits would be more important for the CVD prevention in individuals having diabetes.
diabetes, modifiable risk factor, lifestyle, cardiovascular disease
Accepted manuscripts
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
This content is only available as a PDF.
© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
You do not currently have access to this article.
Download all slides
Comments
0 Comments
Comments (0)
Submit a comment
You have entered an invalid code
Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email.
Sign in
Get help with access
European Society of Cardiology members
Sign in through society site
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Institutional access
- Sign in with a library card
- Sign in with username/password
- Recommend to your librarian
Sign in through your institution
Sign in through your institution
Institutional account management
Sign in as administrator
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Subscription prices and ordering for this journal
Purchasing options for books and journals across Oxford Academic
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Differences in the Association of Lifestyle-Related Modifiable Risk Factors with Incident Cardiovascular Disease Between Individuals with and without Diabetes - 24 Hours access
EUR €38.00
GBP £33.00
USD $41.00
Rental
This article is also available for rental through DeepDyve.
Advertisem*nt intended for healthcare professionals
Citations
Views
Altmetric
More metrics information
Metrics
Total Views 0
0 Pageviews
0 PDF Downloads
Since 7/1/2024
Citations
Powered by Dimensions
Altmetrics
Email alerts
Article activity alert
Advance article alerts
New issue alert
Receive exclusive offers and updates from Oxford Academic
Citing articles via
Google Scholar
-
Latest
-
Most Read
-
Most Cited
More from Oxford Academic
Cardiovascular Medicine
Clinical Medicine
Medicine and Health
Books
Journals
Advertisem*nt intended for healthcare professionals
